The non-Hermitian skin effect is one of the most striking features in non-Hermitian physics. It reveals a novel phenomenon in a non-Hermitian system that the bulk wave function and energy spectrum are sensitively dependent on the boundary conditions. The concept of generalized Brillouin zones has been proposed to characterize bulk wave functions in such systems . Based on generalized Brillouin zones, non-Bloch topological invariants can reconstruct the non-Hermitian bulk-edge correspondence. Previous discussion of the non-Hermitian skin effect mainly focused on open boundary conditions, and the calculation of generalized Brillouin zones needs to be reconsidered under domain-wall boundary conditions. The paper introduces the related researches of the non-Hermitian skin effect in domain-wall systems, including the general form of the generalized Brillouin zone equation in a one-dimensional single-band model, non-Bloch topological invariants in non-Hermitian SSH (Su-Schieffer-Heeger) model, and the experimental realization of the non-Hermitian skin effect in one-dimensional quantum walk system.