In recent years, the property of nonequilibrium thermodynamics in closed system, especially in spin chain system undergoing a quenching process, has become one of the hot topics in the quantum thermodynamics. The nonequilibrium thermodynamic properties of XY spin chain with XZX + YZY type of three-site interaction under a transverse field are studied by considering an exactly solvable model. First we review some basic concepts, i.e., the work distribution, the averaged work, the fluctuation of work, and the irreversible entropy in the nonequilibrium thermodynamics, and give the theoretical model and its solutions. Then, we concretely discuss the effects of the three-site interaction of XZX + YZY type on the average work, the fluctuation of work and the irreversible entropy in the extended XY chain undergoing a quench process. The theoretical calculation and numerical simulation show that the three-site interaction of XZX + YZY type may play a positive and negative role in the increase of the averaged work, which depends on the strength of initial external magnetic field. Moreover, we also find that work fluctuation can be effectively suppressed by adjusting the intensity of XZX + YZY three-site interaction. Finally, it is found that the irreversible entropy production presents a sharp peak characteristic near the critical magnetic field, and the value of the peak sharp decreases with the increase of XZX + YZY three-site interaction. Simultaneously, the corresponding physical explanations are also given. In a word, the results given in present paper may increasingly arouse one’s interest in the nonequilibrium quantum thermodynamics.