High-energy particles’ radiation produces a large number of radiation defects in material, such as interstitial atoms, vacancies, dislocation loops, voids and helium bubbles. The formation and evolution of massive radiation defects cause the instability of microstructure in metal, which further degrades its mechanical performance. Interface engineering is an effective method to tune the radiation resistance of metal and alloy. By introducing a large number of grain boundaries, phase interfaces, free surfaces, etc., the recombination probability of radiation-induced vacancies and interstitial atoms increases, thereby reducing the accumulation of radiation defects, improving the structural stability of the metal and eliminating the harmful effects of radiation. In this paper, we briefly review the recent progress of the mechanisms of interactions between several typical interfaces and various types of irradiation defects. The influence of interface structure, irradiation condition and defect character on their interaction behavior are reviewed and discussed. We also propose some critical questions about the radiation damage to material which remain to be understood. It is necessary to combine multidisciplinary techniques, knowledge and theories in order to fully understand the mechanism of radiation damage and design the advanced radiation-tolerant materials.