High-temperature superconductivity, a fundamental topic in condensed matter physics, presents one of the critical scientific challenges of this century. The potential for breakthroughs in this field not only promises to reveal numerous novel quantum phenomena and deepen our understanding of quantum many-body physics but also to significantly drive advancements in experimental techniques, theories, and methodologies in probing correlated quantum systems. More importantly, as a non-perturbative quantum system, high-temperature superconductivity offers an ideal platform and a crucial driving force for systematically establishing non-perturbative quantum field theory. Currently, research on high-temperature superconductivity stands at a critical turning point. Achieving significant breakthroughs requires the development of cutting-edge detection technologies built upon novel concepts, the establishment of innovative theoretical frameworks and methodologies, and insightful elucidation of the physical pictures revealed by experimental findings. Such extensive exploration is vital for unveiling fundamental relationships and identifying the governing principles. By integrating these efforts, we can gain profound insights into the mechanisms of high-temperature superconductivity and significantly expand the horizons of quantum many-body theory.