As is well known, the evolution of quantum state can be replaced by its Wigner function’s time evolution. The Wigner function of a quantum state is the same as the density matrix of a quantum state, because they both contain many messages, such as the probability distribution and phases. Thus, the important information about the quantum state in the evolution process can be obtained more quickly and effectively by studying the Wigner function of a quantum state. In this paper, based on the classical diffusion equation, the diffusion equation of the quantum state density operator is derived by using the Prepresentation of the density operator. Furthermore, by introducing the Weyl ordering symbol of the quantum operator, the corresponding Weyl quantization scheme is given. In addition, the evolution equation of Wigner operator in diffusion channel is established by using another phase space representation of density operator—Wigner function, and the solution form of Wigner operator is given. In this paper, we derive the evolution law of Wigner operator in quantum diffusion channel for the first time, that is, the form of Wigner operator at any time in the evolution process. Based on this conclusion, the evolution of coherent states through quantum diffusion channels is discussed.