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摘要

超声调制光学成像技术是一种新型的生物组织光学检测技术, 在癌症的早期检测方面具有巨大的潜力, 但该技术在信噪比和成像对比度方面存在不足. 在超声调制光学成像技术的基础上, 结合高灵敏度的激光回馈技术提出了超声调制激光回馈技术, 建立了含微泡介质的蒙特卡罗光子传输模型, 通过仿真和实验研究了超声微泡造影剂增强超声调制激光回馈成像对比度的作用机理. 结果表明, 在透明溶液中, 超声微泡造影剂可以增强超声调制激光回馈信号, 并产生谐波调制, 通过检测回馈基波和谐波信号增强量的方法可提高成像对比度; 而在仿生物组织环境中, 超声微泡造影剂可显著衰减超声调制激光回馈信号, 通过检测回馈基波和谐波信号衰减量的方法可提高成像对比度.

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Abstract

Ultrasound-modulated optical imaging technology is a new type of biological tissue optical detection technology, and sensitive to the change of scattering coefficient and absorption coefficient of biological tissue. This technology is a non-ionizing and non-invasive pathological detection method, which has great potential application in early detection of cancer. However, ultrasound-modulated optical imaging technology is insufficient in signal-to-noise ratio (SNR) and imaging contrast. Frequency-shifted laser feedback technology with microchip laser is a new type of highly sensitive interference technology, whose gain coefficient for weak optical signal can reach 10 ⁶. This technology can greatly improve the SNR of imaging. Combined with the high sensitive laser feedback technology, the ultrasound-modulated laser feedback technology is proposed. The SNR of this technology is better than that of the traditional ultrasound-modulated optical imaging technology. The increase in SNR can achieve greater depth of detection in biological tissue imaging, but there is no significant improvement in imaging contrast. In order to improve the contrast of biological tissue imaging and achieve high resolution imaging of thick biological tissue, we use ultrasound microbubble contrast agent in ultrasound-modulated laser feedback imaging technology. We establish a Monte Carlo photon transport model with microbubbles in order to study the mechanism of contrast enhancement in ultrasound-modulated laser feedback imaging with microbubbles. Finally, we establish an experimental system to verify the correctness of the simulation results. Experimental and simulation results show that in the transparent solution, the ultrasonic microbubble contrast agent can enhance the ultrasound-modulated laser feedback signal and generate harmonic modulation, which can improve the imaging contrast by detecting the enhancement of the fundamental and harmonic signals of the feedback. In the scattering medium, the ultrasonic microbubble contrast agent can significantly attenuate the ultrasound modulated laser feedback signal, and the imaging contrast can be improved by detecting the attenuation of the fundamental and harmonic signal.

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作者及机构信息

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通信作者:谈宜东,tanyd@mail.tsinghua.edu.cn; 沈学举,shxjoptics@aliyun.com;

基金项目:国家自然科学基金(批准号: 51722506)资助的课题

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Corresponding author:Tan Yi-Dong,tanyd@mail.tsinghua.edu.cn; Shen Xue-Ju,shxjoptics@aliyun.com;

Funds:Project supported by the National Natural Science Foundation of China (Grant No. 51722506)

文章全文: translate this paragraph

参考文献

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施引文献

下载: 全尺寸图片幻灯片

${\rho _{\rm{L}}}/{\rm{kg}} \cdot {{\rm{m}}^{ - 3}}$	${P_0}/{\rm{kPa}}$	$\sigma /{\rm{N}} \cdot {{\rm{m}}^{ - 1}}$	$\chi /{\rm{N}} \cdot {{\rm{m}}^{ - 1}}$	$c/{\rm{m}} \cdot {{\rm{s}}^{ - 1}}$	$\varepsilon /{\rm{nm}}$	${\mu _{{\rm{sh}}}}/{\rm{Pa}} \cdot {\rm{s}}$	$\gamma $
998	1010	0.051	0.26	1500	5	0.003	1.07

下载: 导出CSV

溶液种类	背向散射光子数			$\dfrac{{{\simfont\text{调制}} + {\simfont\text{附加调制}}}}{{\simfont\text{未调制}}}$
溶液种类	调制	未调制	附加调制
0.9%的NaCl溶液	9354	45080	0	20.75%
0.9%的NaCl、微泡混合液	9379	46070	4607	30.36%
1%的脂肪乳剂溶液	843	52966	0	1.59%
1%的脂肪乳剂、微泡混合液	97	52685	7	0.20%

下载: 导出CSV

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