Ejecta mixing takes place at the interface between metal and gas under shock loading, i.e., the transport process of ejecta from metal surface appears in the gas. In this paper, adopting disperse particles instead of the initial ejecta, we simulate the ejection mixing process according to two-phase flow of gas and particle. We give the numerical results of the evolution process of the mixing, and analyze the effects of initial gas pressure and particle size on the mixing zone. The pneumatic break is observed from the numerical simulations, which can lead to evident reduction of the particle and then become an important factor affecting the evolution of mixture; also, our simulations are consistent with the corresponding measurements, showing that the gas and particle two-phase flow model is an effective method to simulate the ejection mixing.