Coupled simulation of hypersonic flow and heat exchange is investigated. Moreover, structural stress based on pseudo static assumption is also studied. The unsteady Navier-Stokes equations are solved for the flow field, and SST k-ω model is used as the turbulent model. The unsteady heat conduction equation is solved for the structure. At the fluid-structure interface the flow field acquires temperature boundary condition from the structure and the structure temperature field obtains heat flux boundary condition from flow field. The method proposed here is proved by the slipstream experiment of the infinite circular pipe. The transformation of the temperature and stress of the two-dimensional circular pipe is analyzed in detail during aerodynamic heating. The results show that the high temperature field is gradually enlarged with the increase of aerodynamic heating time. At the same time the structural thermal strain is also gradually enhanced. The minimal deformed area will appear when θ is equal to 60°. The thermal deformation of circular pipe has very little effect on the flow field.