Real-time monitoring and control of welding process is important for laser welding quality. Therefore, the variation rule of sensing characteristics of welding process and their relations to weld quality should be known. Spatter is one of the most important phenomena in high-power laser welding process. The characteristics of spatters are related to the quality and stability of welding and the utilization of the laser power. An approach to analyze the characteristics of spatters is investigated during high-power disk laser bead-on-plate welding of Type 304 austenitic stainless steel plates at a continuous wave laser power of 10 kW. An ultraviolet and visible sensitive high-speed video camera is used to capture the dynamic images of the laser welding spatters. The number, area, and ejecting distance of spatters and the centroid height of spatter images are calculated as the characteristic parameters of spatters by using the image processing technology. The weld bead width is considered as a parameter reflecting the quality and stability of welding process. The linear and the higher order polynomial curve fitting for the data of the characteristic parameters are used to study the variation rule of the characteristic parameters of spatters. In comparison of the fluctuation of the weld bead width, the correlation between the spatter characteristics and the quality and stability of welding is studied. The experimental results of actual laser welding show that the quality and stability of a high-power disk laser welding of Type 304 austenitic stainless steel plates could be monitored and estimated by analyzing the characteristic parameters of spatters, which is the foundation for monitoring and control of welding quality in real time.