For clarifying the response of a bistable system to a high-frequency signal, the mechanism of high-frequency resonance with parameter-adjusted bistable system is investigated. It was shown that the method of twice sampling frequency transformation does not change the bistable system structure to realize resonance at the low frequency corresponding to the high frequency, and that the method of tuning bistable system parameters can directly realize resonance at the high frequency through adjusting the system parameters to change the system structure. The reason for the realization of high-frequency stochastic resonance of tuning system parameters is that adjusting the two parameters of the bistable system simultaneously leads to no limiting value for Kramers rate, and hence the limitation of stochastic resonance frequency within small frequency range is broken through.