The studying of the excitation and propagation characteristics of seabed seismic waves in a complex marine environment is of great significance in investigating seafloor physical and mechanical properties and exploring resources. At present, the research of time-domain seabed seismic waves is mostly restricted in a marine environment with horizontal stratification, but the actual geological conditions of seafloor are relatively complex, and the numerical solutions obtained under ideal assumption are quite different from those in an actual complex environment. To master the propagation characteristics of seabed seismic wave in the environment that is closer to the actual one, a complex and long range model including layers of water, soft mud and bedrocks is designed in the paper, where non-horizontal seafloor topography with a dipping and uplifting structure is considered. The staggered-grid finite difference method with 2nd-order accuracy in time and 10th-order accuracy in space is used to simulate the seabed seismic waves under such a complex marine environment. Meanwhile, multi axial perfectly matched layer is used as an artificial boundary condition to ensure the numerical long-term stability in a liquid-solid medium. Considering the dipping structure, the acoustic signals excited by sources at different positions of the model are compared to determine the favorable style of source excitation for Scholte interface wave receiving. Through the time-domain waveform of the calculated acoustic field, the propagation characteristics of the seabed seismic wave in the complex marine environment are analyzed. The results show that the staggered-grid finite difference method with high-order spatial accuracy can improve the dispersion problem in numerical calculation. The multi-axial perfectly matched layer used to replace the traditional perfectly matched layer can solve the instability problem in the numerical simulation of acoustic field in liquid-solid media for a long range. Through the comparison among the acoustic signal amplitudes excited by sources at different positions, a better performance can be achieved when the source-receiver is placed along the updip direction. In such a case, the acoustic signal is stronger, which is more advantageous to receive and analyze the Scholte interface wave. In the complex seabed model with a dipping and uplifting structure, the uplift of seafloor bedrock changes the propagation direction of Scholte wave, which makes it possible to receive Scholte wave at shallower depth.