Metallic glasses, which exhibit outstanding mechanical, physical, and chemical properties and rich phenomena, are important technologically and fundamentally. The progress in the field of metallic glasses has largely relied on the development of new glass forming alloys. However, due to the multi-component nature of metallic glass, discovery of new alloy is slow. The fabrication combined with high-throughput characterization under the umbrella of materials genome initiative has been demonstrated to be helpful for accelerating the material discovery. In addition, the big data generated during high-throughput characterization can conduce to understanding the science behind the behaviors of various materials. In the paper, we summarize the techniques that can be used for the combinatorial fabrication of metallic glasses, and relevant approaches to realize the high-throughput characterization.