An approach to breaking through the diffraction limitation in infrared microscopies is put forward in this paper. In this method, instead of Gaussian pump beam, an intensive vortex beam is first focused on the sample, leading to the saturation absorption of peripheral molecules in the point spread function (PSF). The vortex beam is followed by a Gaussian probe beam with the same wavelength. Because of the previous saturation absorption, the probe beam can only be absorbed by the molecules near the center, resulting in a shrunk PSF which means super-resolution. Furthermore, the PSF of a system based on this approach is numerically simulated. With a 100 nJ pulse energy vortex beam and a 0.1 nJ pulse energy probe beam, the theoretical resolution FWHM (full width at half maximum) is measured to be about 236 nm which is 14 times better than that of the traditional infrared microscopy.