Cavity optomechanics originated from the research of interferometric detection of gravitational waves, and later became a fast-growing area of techniques and approaches ranging from the fields of atomic, molecular, and optical physics to nano-science and condensed matter physics as well. Recently, it focused on the exploration of operating mechanical oscillators deep in the quantum regime, with an interest ranging from quantum-classical interface tests to high-precision quantum metrology. In this paper, recent theoretical work of our group in the field of quantum measurement with cavity optomechanical systems is reviewed. We explore the quantum measurement theory and its applications with several unconventional cavity optomechanical schemes working in the quantum regime. This review covers the basics of quantum noises in the cavity optomechanical setups and the resulting standard quantum limit of precision displacement and force measurement. Three novel quantum measurement proposals based on the hybrid optomechanical system are introduced. First, we describe a quantum back-action insulated weak force sensor. It is realized by forming a quantum-mechanics-free subsystem with two optomechanical oscillators of reversed effective mass. Then we introduce a role-reversed atomic optomechanical system which enables the preparation and the quantum tomography of a variety of non-classical states of atoms. In this system, the cavity field acts as a mechanical oscillator driven by the radiation pressure force from an ultracold atomic field. In the end, we recommend a multimode optomechanical transducer that can detect intensities significantly below the single-photon level via adiabatic transfer of the microwave signal to the optical frequency domain. These proposals demonstrate the possible applications of optomechanical devices in understanding of quantum-classical crossover and in achieving quantum measurement limit.