Current network security defense strategy focuses on deploying to high degree nodes where there are mainly two aspects of the problem: One is that the high-degree nodes are not the backbone nodes for the network communication in many occasions; another is that these nodes are not always the most effective ones for forwarding and propagation information. With the disadvantage of current network defense strategy deployment, this paper tends to improve the traditional diffusion model of malicious program propagation and measure the importance of network nodes by using intermediate hops, then the important node for recommended deployment technology based on betweenness center control and closeness center control model is put forward. Experimental results show that the nodes with high betweenness centrality and low closeness centrality as compared with the high degree nodes can more effectively quarantine the spreading of the worms whether in scale-free network or in small world network. Meanwhile, the clustering behavior of a network will also play a certain negative impact on the spread of malicious programs.