The active disturbance rejection control (ADRC) has the property of requiring no knowledge about the precise mathematical model, but the parameters of controller is difficult to be tuned. An active disturbance rejection control based on immune binary-state particle swarm optimization algorithm (IBPSO-ADRC) is proposed, which takes advantage of the combination of the artificial immune systems (AIS) and particle swarm optimization (PSO). The proposed algorithm is applied to optimize the parameters of ADRC and then to control chaotic system. Furthermore, a new ADRC for the chaotic system is constructed. The simulation experiments indicate that the scheme requires no knowledge about the mathematical model with fast response speed, while restraining the parameter perturbation of chaotic system effectively and is robust to noise.